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Asunaprevir (BMS-650032): Advanced Insights into NS3/4A P...
2025-09-25
Explore the multifaceted antiviral potential of Asunaprevir, a potent HCV NS3 protease inhibitor, with an in-depth focus on its molecular mechanism, selectivity, and impact on hepatitis C virus infection and cellular signaling pathways. This article offers unique scientific perspectives and comparative analysis beyond existing reviews.
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Asunaprevir (BMS-650032): Systems Biology Insights into H...
2025-09-24
Discover the multifaceted role of Asunaprevir (BMS-650032), a leading HCV NS3 protease inhibitor, in antiviral research. This article uniquely explores systems biology perspectives, signaling pathways, and its implications for advanced hepatitis C virus infection models.
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Asunaprevir (BMS-650032): Mechanistic Advances in HCV NS3...
2025-09-23
Explore the latest mechanistic insights into Asunaprevir (BMS-650032), a potent HCV NS3 protease inhibitor, with a focus on its molecular interactions, hepatotropic drug distribution, and research applications in antiviral agent development for hepatitis C.
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Asunaprevir (BMS-650032): Advances in HCV Protease Inhibi...
2025-09-22
Explore the mechanistic advances and research applications of Asunaprevir (BMS-650032), a potent HCV NS3 protease inhibitor. This article examines its antiviral efficacy, distribution, and relevance in hepatitis C virus infection studies.
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5-Ethynyl-2'-deoxyuridine (5-EdU) in Stem Cell Proliferat...
2025-09-19
Explore how 5-Ethynyl-2'-deoxyuridine (5-EdU) advances click chemistry cell proliferation detection, with a focus on stem cell biology and male fertility research. This article highlights recent mechanistic insights and practical protocols for robust S phase DNA synthesis detection.
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SM-164: Mechanistic Advances in IAP Antagonism and Apopto...
2025-09-18
This article examines SM-164, a bivalent Smac mimetic and potent IAP antagonist for cancer therapy, emphasizing its unique role in apoptosis induction in tumor cells and recent insights from apoptosis signaling research. Discover how SM-164 advances cancer research through targeted cIAP-1/2 and XIAP inhibition.
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In silico docking analysis performed in
2025-03-03
In silico docking analysis performed in the current study indicated that TCDD strongly binds to AhR-LBD. Moreover, the formation of the TCDD/AhR-LBD complex was confirmed experimentally with the use of EMSA. We found that 10nM TCDD after 2 hours of incubation not only bound to the AhR in the porcine
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br Preliminary remarks Expression of the
2025-03-03
Preliminary remarks Expression of the transcription factor aryl hydrocarbon receptor (AHR) and the AHR-repressor (AHRR) are both strikingly high in the UCB 35625 of barrier organs skin and gut [1,2]. It is generally assumed that this reflects their role in linking environmental factors to an ada
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The numbers and types of
2025-03-03
The numbers and types of molecules needing to be transported across membranes are very large, and there is a corresponding very large and diverse number of transporters expressed throughout the body. Hundreds of proteins that have been assigned as having transporter function are broadly divided into
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However although in vitro studies
2025-03-03
However, although in vitro studies in heterologous systems have provided very important indications of potential novel pharmacology, the studies with endogenous receptors in native tissues are essential to provide evidence for GPCR heteromerization in vivo and to confirm its physiological relevance.
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The indirect effect of corporate taxation as given
2025-03-03
The indirect effect of corporate taxation, as given by the second term in Eq. (18), consists of two elements; (i) a standard Berberine Sulfate effect (τ/n2), and (ii) a capital cost effect (rG(1−αt)/(1−t)). With a CRS technology, the cost effect vanishes, whereas with an IRS (a DRS) technology the c
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br AD and COX LOX pharmacology
2025-03-03
AD and COX/5-LOX pharmacology Early studies on the role of cyclooxygenases in AD were inspired by epidemiological data suggesting that COX inhibitors such as nonsteroidal anti-inflammatory drugs (NSAIDs) could be beneficial in AD patients (Lucca et al., 1994, McGeer et al., 1990). This line of re
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The c C T mutation identified in subject
2025-03-03
The c.286C>T mutation identified in subject K20-1 was also reported in other ethnic groups, including Brazilian, French-Canadian, Italian, and Arabs from the United Arab Emirates [20], [21], [22], whereas c.318A>G mutation in subjects K10-1 was previously reported in Asian and Caucasians [13], [23],
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Because the V ATPase inhibitors that have
2025-03-03
Because the V-ATPase inhibitors that have been employed in these studies (including bafilomycin and concanamycin), are membrane permeant, they inhibit all the V-ATPases in the cell. This is important since it is possible that intracellular V-ATPases, in addition to those present at the plasma membra
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br Materials and methods br Results br
2025-03-01
Materials and methods Results Discussion Because the Ser/Thr kinase domain of LRRK2 is homologous to that of other MLK family proteins belonging to the MAP3K superfamily, LRRK2 is suggested to be involved in MAPK signaling and activation of neuronal cell death by phosphorylating its downstr