• In some of our studies we examined

  2021-07-07

  

  In some of our studies we examined the occurrence of ERβ and SHBG and a possible colocalization between them. Fig. 5 shows that there is no big difference in the occurence of ERβ after short time (A) as well as long time (B) treatment with E2. We can find the receptor at the cell membrane as well as

• It is well established that a number

  2021-07-07

  

  It is well established that a number of intracellular signaling pathways mediate sensitization of sensory neurons (Gold and Gebhart, 2010, Richardson and Vasko, 2002). This redundancy could be advantageous since it provides diversity in initiating and maintaining hypersensitivity in response to inju

• The UPP broadly involves proteolysis in biochemical

  2021-07-06

  

  The UPP broadly involves proteolysis in biochemical processes and is a potential target for cancer therapy. The UPP degrades unfolding or damaged proteins by an ATP-dependent mechanism (Ciechanover, Elias, Heller, Ferber, & Hershko, 1980). It also plays an important role in Laminin 925-933 regulatio

• Further indirect evidence supporting an

  2021-07-06

  

  Further indirect evidence supporting an important role of DPP-4 in the modulating the actions of both incretins comes from the observations that analogues of GLP-1 and GIP, modified to be resistant to DPP-4 cleavage, were subsequently shown to have greater metabolic stability in vivo which was assoc

• br How does DDR receptor activated

  2021-07-06

  

  How does DDR2 receptor activated to induce Osteoarthritis Alternation of joints by mechanical stress produces microcracks and deterioration of natural pores in subchondral bone provides Aprotinin for cross talk through diffusion of small molecules [26,27]. At early stage of OA, chondrocytes in th

• Some mechanistic experiments performed in

  2021-07-06

  

  Some mechanistic experiments performed in the early 2000s by Ongusaha et al. [78], suggest that DDR1 induction protects acetylcholine chloride sale from apoptosis in a p53-dependent manner, and that impairment of DDR1 expression or function leads to a pronounced increase of DNA damage-induced apopt

• In summary our data show a novel

  2021-07-06

  

  In summary, our data show a novel mechanism: CPD-mediated autoprocessing of C difficile toxins regulates their proinflammatory activities. Thus, our study provides a new understanding of the molecular mechanisms of the pathogenesis of C difficile toxins and insights into designing new therapeutics a

• br Fragment based drug discovery FBDD is a powerful method

  2021-07-06

  

  Fragment-based drug discovery (FBDD) is a powerful method to discover drug leads and has been widely adopted in both academia and industry. FBDD can be used to explore chemical hsp90 inhibitor space with libraries which are smaller in size, producing drug leads with high ligand-binding efficiency

• In this study we observed alterations

  2021-07-06

  

  In this study, we observed alterations in mRNA levels of CRF receptors in the PFCx and Hip during the development of sensitization. In particular, in the Hip both CRF receptors showed significantly increased ω-Agatoxin TK when the sensitization condition was established. Similarly, CRF2 receptor in

• In recent years there has been much

  2021-07-06

  

  In recent years, there has been much interest within the endothelin community regarding the possibility that ETA and ETB receptors may form homo- and heterodimers. Heterodimerization of endothelin receptors may provide an explanation for the results mentioned in the previous paragraph and might also

• Propidium iodide br Introduction Breast cancer is the most c

  2021-07-06

  

  Introduction Breast cancer is the most common malignant tumor in women and the second leading cause of female death [1]. In recent years, with the improvement of early detection and the emergence of new treatment methods, the mortality rate of breast cancer has been greatly reduced. However, the

• The expression of DDR receptor has regulated by numerous typ

  2021-07-06

  

  The expression of DDR2 receptor has regulated by numerous types of factors depending upon the cell type. During the osteogenic differentiation, the transcription factorATF4 combined with CCAAT/enhancer binding site in the DDR2 promoter, which is responsible for induction of DDR2 transcription [24].

• Among the Ub interactions observed in the

  2021-07-05

  

  Among the ~Ub interactions observed in the HOIP structure is one that involves a RING2 domain (from the non-cognate HOIP) [47]. A similar binding interaction was defined between HHARI RING2 and the hydrophobic patch on Ub by NMR [54]. HHARI RING2 mutations that ablate the interaction inhibit formati

• One of the most fundamental distinctions

  2021-07-05

  

  One of the most fundamental distinctions between Ub signals is substrate monoubiquitination versus polyubiquitination. With the exception of the E2, UBE2W, which represents a special case because it JWH 133 synthesis only ubiquitinates the flexible N-termini of substrates [5], [6], [20], most examp

• br Methods br Results br Discussion Preclinical data indicat

  2021-07-05

  

  Methods Results Discussion Preclinical data indicate that nepicastat modulates sympathetic drive to the GW5074 with a mild pressor effect in various animal models of hypertension (Stanney et al., 1998). However in this clinical study, the doses of nepicastat employed did not significantly

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