• Importantly the levels of the pro

  2022-01-17

  

  Importantly, the levels of the pro-inflammatory cytokines TNF-α and IL-1β and Nf-κB, a key transcription factor in chronic inflammatory responses that is activated by pro-inflammatory cytokines, were also reduced by the drugs, confirming our previous results that demonstrated anti-inflammatory effec

• br Discussion RBCs possess a much

  2022-01-17

  

  Discussion RBCs possess a much simpler composition and structure than other eukaryotic N-Nonyldeoxynojirimycin and can therefore serve as a convenient system on which to study how cell functioning relates to the molecular and supramolecular properties of its constituents. The model developed in

• Until recently the mechanism of how GSMs shifted secretase

  2022-01-17

  

  Until recently the mechanism of how GSMs shifted γ-secretase cleavage was poorly understood. Today, building on the sequential cleavage model developed by Ihara and colleagues [14], there is evidence that GSMs act as processivity enhancers, and iGSMs as inhibitors of processivity [120]. At least for

• With rare exceptions the biological

  2022-01-17

  

  With rare exceptions, the biological role of γ-secretase cleavage of substrates other than Notch 1 has been ignored during proof of concept preclinical repurposing studies. For example, in the GSI AD trial, many individuals noted changes in hair color, apparently due to inhibition of tyrosinase, ano

• Ning et al showed that LPC appeared to

  2022-01-17

  

  Ning et al. showed that LPC 18:1 appeared to increase insulin release through both GPR119-dependent and -independent mechanisms (Ning et al., 2008). In our study, we have shown that not only GPR119 but also GPR40 and GPR55 participate in LPC-stimulated insulin secretion (Fig. 4, Fig. 5) and target p

• hydrocort br Results br Discussion In this study

  2022-01-15

  

  Results Discussion In this study, six new T30695 variants were synthesized with the acyclic R or S glycerol linker instead of hydrocort unit at 4, 8 or 12 T residue. Based on our previous studies on TBA-GQ, this type of modification should provoke local changes in GQ conformations in the final

• Describing histone acetylation machinery in rivulus will pro

  2022-01-15

  

  Describing histone acetylation machinery in rivulus will provide a basis for understanding the role of epigenetic mechanisms in mediating phenotypic variation, by guiding both phenotypic flexibility in adults and developmental plasticity in young. Together with its biological characteristics, rivulu

• br Introduction Adipose tissue AT in addition to its

  2022-01-15

  

  Introduction Adipose tissue (AT), in addition to its function as BH3I-1 storage, is an important endocrine organ and it secretes adipokines (Ahima, 2006). Adipose tissue is related to different physiological processes such as energy metabolism, insulin sensitivity, and inflammation. One importan

• Percentage contribution to free glutamate intake was also ca

  2022-01-15

  

  Percentage contribution to free glutamate intake was also calculated at the food item level. A list of the top 30 foods for children and adults are presented separately in Table 2. The top 4 foods included in this list are watermelon, raw; tomato catsup; tomatoes, raw; and roll, white, soft. These a

• br Acknowledgements This work was supported by

  2022-01-15

  

  Acknowledgements This work was supported by the Science and Technology Department of Hubei Province (No.2016CFB368) and the National Natural Science Foundation of China (No. 81201053). Introduction L-Glutamate (glutamate) is the most important excitatory neurotransmitter of the central nervou

• How do myofibroblast sources compare between

  2022-01-15

  

  How do myofibroblast sources compare between bone marrow and other organs? Perivascular MJ33 lithium salt receptor with MSC properties significantly contribute to fibrosis in muscle, fat, skin, heart, kidney, lung, and liver (reviewed in Iwayama et al., 2015) and activate Gli1 in many of these orga

• The role of GJs in liver fibrogenesis was studied

  2022-01-15

  

  The role of GJs in liver fibrogenesis was studied recently. Studies showed a significant decrease in liver fibrosis in Cx32 knockout mice compared to wild-type mice. Although the mechanism underlying this protective effect of Cx32 deletion is not clear, reduced oxidative stress was suggested as a po

• br Materials and methods br Results and

  2022-01-15

  

  Materials and methods Results and discussion Conclusions Notes Declaration of interest statement Acknowledgment This work was supported by the National Natural Science Foundation of China (No. 21775132, 21505112), Scientific Research Foundation of Hunan Provincial Education Departm

• The extensive worldwide research efforts in

  2022-01-14

  

  The extensive worldwide research efforts in the decade following FFA1 de-orphaning aimed at developing clinically useful FFA1 agonists were nearly halted after Takeda’s first-in-class agent fasiglifam (TAK-875) was discontinued in phase III of human trials. On the date of submission of this manuscri

• Together the epigenetic interplay revealed in this study ena

  2022-01-14

  

  Together, the epigenetic interplay revealed in this study enabled us to expand the therapeutic potential of EZH2is from hematological malignances to solid tumors. In solid tumors, EZH2i-driven transcriptional changes are shown to be dispensable of H3K27me-regulated transcriptional network. Instead,

14192 records 480/947 page Previous Next First page 上5页 476477478479480 下5页 Last page