• br Declaration of interest br

  2023-08-30

  

  Declaration of interest Funding Introduction The endocrine disruptor bisphenol A (BPA) is a high-production chemical used in several consumer products, including polycarbonate bottles, epoxy resins, dental sealants, and thermal paper receipts (Geens et al., 2012). Importantly, BPA monomers

• br Apelin The APJ receptor ligand apelin firstly

  2023-08-30

  

  Apelin The APJ receptor ligand apelin firstly in 1998 was segregated from bovine stomach tissue. Human preproapelin gene located on chromosome Xq25–26.1. The apelin preproproteins consist of 77 amino lpl receptor residues that are cleaved into biologically active C-terminal fragments of various

• br Materials and methods br Results br Discussion

  2023-08-30

  

  Materials and methods Results Discussion Prostate cancer is the most common cancer in men in the United States and the second leading cause of cancer death. Therapeutic interventions include mainly: radical prostatectomy or radiation therapy (RT), with or without androgen deprivation therap

• br Materials and methods br Results Table presents the

  2023-08-30

  

  Materials and methods Results Table 1 presents the metabolic phenotype of obese minipigs. After 60 d of HFHS feeding, minipigs not only showed an increased body weight (+45%), but also a perturbed CBiPES hydrochloride homeostasis, with higher insulin levels (about +2-fold), HOMA-IR (+5.5-fold

• Introduction Lipoxygenases LOXs are key enzymes that catalyz

  2023-08-30

  

  Introduction Lipoxygenases (LOXs) are key enzymes that catalyze the polyunsaturated fatty acids (PUFAs) such as arachidic BCA Protein Quantitation Kit (AA), linoleic acid (LA) and others unsaturated fatty acids (Brash, 1999). LOXs are expressed in immune, neural, epithelial, tumor cells and other c

• br Stress glucocorticoids as risk factor for Alzheimer s

  2023-08-30

  

  Stress/glucocorticoids as risk factor for Alzheimer’s Disease: preclinical studies A role for glucocorticoids in shaping the risk for AD is supported by animal studies using rats or mice injected with Aβ oligomers, tau protein or excitotoxins, or transgenic (Tg) mice carrying mutations associated

• Sphingolipids such as ceramides and glucosylceramides are an

  2023-08-30

  

  Sphingolipids, such as ceramides and glucosylceramides, are an important class of bioactive lipids. The levels of these lipids change as a function of adipose tissue mass and functionality, and are partially driven by cellular availability of palmitoyl-CoA. Aberrant accumulation of ceramide, glucos

• Our co IP data show that HT A or HT

  2023-08-30

  

  Our co-IP data show that 5HT1A or 5HT2A receptors do not heterodimerize with mGluR1α receptors. Given that both 5-HT and mGlu receptors are GPCRs and produce anxiolytic effects, a degree of cooperativity via a functional cross-talk may still exist between these receptors [11]. In addition to the fun

• We further analyzed selected hit compounds for their

  2023-08-29

  

  We further analyzed selected hit compounds for their ability to inhibit human AdK in intact cells. Human 1321N1 astrocytoma RNA were utilized which were found to express AdK. The whole cell assay was performed using a 96-well format. The standard AdK inhibitor 5-iodotubercidin was employed as a pos

• As a continuation of our search for a selective AChE

  2023-08-29

  

  As a continuation of our search for a selective AChE radioligand bearing a meta-F substituted N-benzyl moiety, we designed and synthesized a novel meta-F-CP-118,954 analog along with a meta-18F-labeled form via diaryliodonium salt-based precursor (Fig. 1). For comparative purposes, we incorporate th

• br Conflicts of interest br Acknowledgments The authors

  2023-08-29

  

  Conflicts of interest Acknowledgments The authors acknowledge National Institute for Medical Research Development (NIMAD) project no. 940943 and National Research Institute for Science Policy (NRISP) no. 1456 for financial support of this work. AM appreciates National Institute for Genetic Eng

• br Materials and methods br Results

  2023-08-29

  

  Materials and methods Results Discussion Despite the relative complexity of immunotherapy, such treatment may have an important role, in conjunction with other therapies in the treatment of cancer refractory to conventional treatments alone. Clinical studies have recently shown that adding

• The fluorescence in a fluorescent antibiotic can be derived

  2023-08-29

  

  The fluorescence in a fluorescent antibiotic can be derived either from functional groups with intrinsic fluorescence in an existing antibiotic, or via synthetic conjugation of a fluorophore to an antibiotic core to enable visualisation. Attachment of fluorophore to an antibiotic should ideally not

• The radiographic correlate will be similarly important

  2023-08-29

  

  The radiographic correlate will be similarly important for the success of other non-VEGF TKIs, such as those targeting the epidermal growth factor receptor expressed in 50% of high-grade primary PLX4032 neoplasms. It has been reported that icotinib and gefitinib, epidermal growth factor receptor–TK

• Finally microRNAs miRNA seem to play an important role

  2023-08-29

  

  Finally, microRNAs (miRNA) seem to play an important role in AR signaling in BC. Some authors have described a differential ampa receptors of miRNAs in AR-positive BCs compared to AR-negative ones. VEGF and mTOR pathways were also reported as implicated in miRNA dysregulation, suggesting a common u

14484 records 288/966 page Previous Next First page 上5页 286287288289290 下5页 Last page